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Acute and chronic electrical activation of baroreceptor afferents in awake and anesthetized subjects BJMBR
Durand,M.T.; Fazan Jr.,R.; Salgado,M.C.O.; Salgado,H.C..
Electrical stimulation of baroreceptor afferents was used in the 1960's in several species, including human beings, for the treatment of refractory hypertension. This approach bypasses the site of baroreceptor mechanosensory transduction. Chronic electrical stimulation of arterial baroreceptors, particularly of the carotid sinus nerve (Hering's nerve), was proposed as an ultimate effort to treat refractory hypertension and angina pectoris due to the limited nature of pharmacological therapy available at that time. Nevertheless, this approach was abandoned in the early 1970's due to technical limitations of implantable devices and to the development of better-tolerated antihypertensive medications. More recently, our laboratory developed the technique of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Carotid sinus nerve; Aortic depressor nerve; Hemodynamics; Baroreceptor stimulation; Refractory hypertension.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000100009
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Continuous blood purification treatment for endotoxin-induced acute respiratory distress syndrome BJMBR
Jiang,Y.; Lin,R.; Xu,Y.; Zhang,S.; Cui,K.; Zhu,M.; Li,A.; Chen,C.; Yang,J.; Yang,W..
This study aimed to explore the effects of continuous blood purification (CBP) treatment in pigs affected with acute respiratory distress syndrome (ARDS). A total of 12 healthy male pigs, weighing 12±1.8 kg, were randomly and equally assigned to the control and experimental groups. The ARDS pig model was prepared by intravenous injections of endotoxin (20 µg/kg). The control group was given conventional supportive therapy, while the experimental group was given continuous veno-venous hemofiltration therapy. During the treatment process, the variations in dynamic lung compliance, oxygenation index, hemodynamics, and urine volume per hour at different times (Baseline, 0, 2, 4, and 6 h) were recorded. The levels of tumor necrosis factor (TNF-α), interleukin 6...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acute respiratory distress syndrome; Continuous blood purification treatment; Endotoxin; Hemodynamics.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000200604
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Echocardiographic reference ranges for sedated healthy peccaries ( Tayassu tajacu, Linnaeus , 1758 ) Arq. Bras. Med. Vet. Zootec.
Moura,L.S.; Rodrigues,R.P.S.; Silva,A.B.S.; Pessoa,G.T.; Sousa,F.C.A.; Barbosa,M.A.P.S.; Souza,A.B.; Alves,J.J.R.P.; Macedo,K.V.; Diniz,A.N.; Silva,E.G.; Araújo,J.R.; Marques,D.C.; Cavalcante-Filho,M.F.; Alves,F.R..
ABSTRACT Peccaries are wild mammals belonging to the Tayassu genus that are found almost everywhere in the Americas and have demonstrated great potential as an experimental model for scientific investigations. Twelve healthy adult animals were sedated to perform echocardiographic examinations in B, M and Doppler mode. The variables that exhibited statistically significant correlation coefficients with weight were LVFWd, LVIDd, LVIDs, E wave, A’RV, MAM, and TAPSE. The HR exhibited a negative relationship with the IVRT. The LA variable showed a positive correlation with the AO. The MAM exhibited correlations with the LVIDd and LVIDs. The TAPSE showed positive correlations with the E’RV and A’RV. The present study provides the first reference values for...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cardiology; Wild animals; Diagnostic imaging; Heart; Hemodynamics.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352019000100068
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Enhanced external counterpulsation improves cardiac function in Beagles after cardiopulmonary resuscitation BJMBR
Xiong,Jing; Zhang,Wei; Wei,Hongyan; Li,Xin; Dai,Gang; Hu,Chunlin.
The aim of this study was to investigate the influence of enhanced external counterpulsation (EECP) on the cardiac function of beagle dogs after prolonged ventricular fibrillation. Twenty-four adult male beagles were randomly divided into control and EECP groups. Ventricular fibrillation was induced in the animals for 12 min, followed by 2 min of cardiopulmonary resuscitation. They then received EECP therapy for 4 h (EECP group) or not (control group). The hemodynamics was monitored using the PiCCO2 system. Blood gas and hemorheology were assessed at baseline and at 1, 2, and 4 h after return of spontaneous circulation (ROSC). The myocardial blood flow (MBF) was quantified by 18F-flurpiridaz PET myocardial perfusion imaging at baseline and 4 h after ROSC....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cardiopulmonary resuscitation; Hemodynamics; Enhanced external counterpulsation; PiCCO2; Myocardial blood flow; Beagle dog.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000100609
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Hemodynamic and thermoregulatory effects of xylazine-ketamine mixture persist even after the anesthetic stage in rats Arq. Bras. Med. Vet. Zootec.
Picollo,C.; Serra,A.J.; Levy,R.F.; Antonio,E.L.; Santos,L. dos; Tucci,P.J.F..
The xylazine-ketamine mixture (KX) is an anesthetic approach commonly administered to assess cardiovascular function in rodents. This study aimed to examine if the cardiovascular and thermoregulatory effects of KX could persist after the anesthetic state ceased in rats. Male Wistar rats were anesthetized with K (50mg/kg) X (10mg/kg) through the intra-peritoneal route. Hemodynamic and thermoregulatory repercussions were evaluated in animals in awake state, during an anesthetic depth and after complete recovery of anesthetized state. KX was efficient to significantly induce deep anesthesia in all rats after 10min. A complete recovery of anesthetized state was observed only after 210min. Compared with preanesthetic state and control animals that received no...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Anesthesia; Hypotension; Xylazine-ketamine; Hemodynamics; Thermoregulation.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352012000400011
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Rats with high left ventricular end-diastolic pressure can be identified by Doppler echocardiography one week after myocardial infarction BJMBR
Saraiva,R.M.; Kanashiro-Takeuchi,R.M.; Antonio,E.L.; Campos,O.; Tucci,P.J.F.; Moisés,V.A..
The severity of left ventricular (LV) dysfunction in rats with myocardial infarction (MI) varies widely. Because homogeneity in baseline parameters is essential for experimental investigations, a study was conducted to establish whether Doppler echocardiography (DE) could accurately identify animals with high LV end-diastolic pressure as a marker of LV dysfunction soon after MI. Direct measurements of LV end-diastolic pressure were made and DE was performed simultaneously 1 week after surgically induced MI (N = 16) or sham-operation (N = 17) in female Wistar rats (200 to 250 g). The ratio of peak early (E) to late (A) diastolic LV filling velocities and the ratio of E velocity to peak early (Em) diastolic myocardial velocity were the best predictors of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Heart failure; Myocardial infarction; Echocardiography; Hemodynamics.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100016
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Swimming training increases cardiac vagal activity and induces cardiac hypertrophy in rats BJMBR
Medeiros,A.; Oliveira,E.M.; Gianolla,R.; Casarini,D.E.; Negrão,C.E.; Brum,P.C..
The effect of swimming training (ST) on vagal and sympathetic cardiac effects was investigated in sedentary (S, N = 12) and trained (T, N = 12) male Wistar rats (200-220 g). ST consisted of 60-min swimming sessions 5 days/week for 8 weeks, with a 5% body weight load attached to the tail. The effect of the autonomic nervous system in generating training-induced resting bradycardia (RB) was examined indirectly after cardiac muscarinic and adrenergic receptor blockade. Cardiac hypertrophy was evaluated by cardiac weight and myocyte morphometry. Plasma catecholamine concentrations and citrate synthase activity in soleus muscle were also determined in both groups. Resting heart rate was significantly reduced in T rats (355 ± 16 vs 330 ± 20 bpm). RB was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Swimming-training exercise; Cardiac autonomic balance; Hemodynamics; Hypertrophic effect; Parasympathetic system; Resting bradycardia.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001200018
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The effects of positive end-expiratory pressure on respiratory system mechanics and hemodynamics in postoperative cardiac surgery patients BJMBR
Auler Jr.,J.O.C.; Carmona,M.J.C.; Barbas,C.V.; Saldiva,P.H.N.; Malbouisson,L.M.S..
We prospectively evaluated the effects of positive end-expiratory pressure (PEEP) on the respiratory mechanical properties and hemodynamics of 10 postoperative adult cardiac patients undergoing mechanical ventilation while still anesthetized and paralyzed. The respiratory mechanics was evaluated by the inflation inspiratory occlusion method and hemodynamics by conventional methods. Each patient was randomized to a different level of PEEP (5, 10 and 15 cmH2O), while zero end-expiratory pressure (ZEEP) was established as control. PEEP of 15-min duration was applied at 20-min intervals. The frequency dependence of resistance and the viscoelastic properties and elastance of the respiratory system were evaluated together with hemodynamic and respiratory...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Postoperative cardiac surgery; PEEP; Respiratory mechanics; Hemodynamics.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000100005
Registros recuperados: 8
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